The difference between the two happens with the midrange and the extended bass of the M50s. The M22s have the better mids. I didn't notice any appreciable difference in the higher ranges. M3s are out of the question? I don't want to ruffle any feathers, but I'll go out on a limb and say that the M3/M50 clan might have the better 'smooth ride music only' speaker vs the M22. But, I bet the M60/M80s is probably the best for both worlds.