I've compared my M22's to my onwall 22's side by side and they both sound very similar in the mid's and highs, however, the regular M22's did do better in the lower bass frequencies. This would be expected with the larger enclosure.

However, once you include a sub in the mix and have a proper crossover setting, there is little difference.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85