As far as a "would it work" perspective, I don't think I'd use QS8s, as those are 6 ohm speakers. You'd end up presenting a 3 ohm load to your receiver/amp, which is a tad low, unless you have a pro amp.

That said, I'm sure someone around here is nutso enough to run a pair of M80s on one channel or something insane like that.

I am the Doctor, and THIS... is my SPOON!