Do you have a picture of the stand or something similar to help visualize? Will the sound be impacted vs a direct, unblocked setup? Yes, will it be terrible? Don't know, honestly, but the picture would be helpful to see how much bulk is there.
As a positive note, this is potentially more "doable" with a sub vs. with a regular speaker, so at least that is going for you.
The EP350 is front firing, so you generally want that as unobstructed as possible.
M60s, VP180, VP150, QS8s, M3s, SVS 20-39PCi, Shakers