By the sound of it the LFR1100 would be far more position critical than M100?
I think the resounding answer is "yes".
Now, I own neither product (and actually haven't even heard them, yet), so my answer is based primarily on study of the Axiom product line and design philosophy over the years.
The LFR1100 will simply have more interaction with the room than a direct-radiating speaker (like the M80 or M100). The LFR series relies on direct and reflected sound, so positioning relative to the back wall and other boundaries is more important.
I'm sure that the LFR1100's would sound very lovely in that room. My concern is that you don't seem to have much latitude regarding the main speaker placement relative to the rear wall, side walls or furniture. As such, you may not be able to optimize their omnidirectional properties. But they certainly wouldn't sound WORSE than the M100's.
And - who knows - you might like them better than your B&W's and rearrange everything!