combined with a velodyne sub,qs4 and vp100.

When you use it with a sub and have it set to small with an 80-90 Hz crossover on ur preamp/processor or reciever, it should be sufficent.

It will work fine unless you really try to push them hard. The M22's will start to strain when you try to play really loud in a room that size. (85db+) But for normal listening they'll sound wonderful.