I'd place the speakers at about the same height as the TV and about 8 to 9 feet apart, given the distance you sit from the TV. My M22s were on Full Metal Brackets until recently -- we're trying a new living room arrangement at the moment -- and I didn't have them toed in. I did have them angled down slightly, though. I used the included hard plastic wedges to do it, and not by adjusting the bracket itself. I found that the bracket's ridges were spaced a little too far apart to be aimed where I wanted them.
"I wish I had documented more…" said nobody on their death bed, ever.