It'll be interesting also to see how the VP160 will sound with my 2 pair of M22 mains with EP350. Panning from side to side "might" be noticeable, but maybe not by that much. I'm hopeful for deeper male vocals and better bass guitar. I plan on setting L/R M22's to small (Cut off at 80hz), and VP160 center to Large (no cutoff).
Prior to obtaining my current M80s, I had M22s as my mains. Because of the cabinet and driver size of the VP160, I would suspect there would be a natural noticeable difference since even if you had, for example, both the M22s and VP160 set for an 80HZ cutoff, of course, as you know, these crossovers are gradual and you would still hear some direct sounding bass(60>80HZ) in the VP160 that the M22s are not capable of producing to the same degree anyway. In my opinion, the VP160 set to LARGE would probably even be more noticeable. (M60s/80s here we come?).