Acoustically, no, M80’s aren’t too big. Physically, yah, probably. I’m having troubles arranging mine in a 12’ X 15’ room along with an EP600 and a pair 22’s being used as a center. The whole front wall is nothing but drivers. They’re fairly tall speakers too, which is governing my screen size and its height off the floor.

If I were you, my primary concern would be layout and size of the speakers. Remember, Axioms are rear ported and they really do need to be placed a few inches away from the wall, which compounds space limitation issues.