Anthony, you're all over the place...reminds me of where I was at last November \:\) So many choices, so many things to think about. I had an old Sony receiver, 50w I think, and some even older Kenwood speakers that worked fine for me for years. The only reason I was looking at upgrading was because I was looking at a new TV and didn't think my crappy old audio equipment would do the new TV justice.

I ended up throwing my budget out the window and got the Epic 60-600 system along with a Denon 3808. I couldn't be more pleased.

Anyways, on to your situation...

2xM60 + VP150 + 2xQS8 + RX-V663 (config you listed)
Not bad. I love my M60s, they produce more bass than I thought they would, but without a sub it's still not enough for my liking.

M60 + VP150 + QS8 + EP350 + RX-V663
I think this would sound much better than the above config.

M22 + VP100 + QS4 + EP175 + RX-V663
If budget is a big concern, this setup is worth considering.

2xM80 + VP150 + 2xQS4 + 3808 (config you listed)
This doesn't look bad, but if you are going to spend this much money you might as well spend the extra $150 and upgrade to the QS8.