Speaker cable does make a significant difference in the tonal quality of the music you listen to. The inner twisting of the wire and it's design, causes the current of the signal to be reproduced with more accuracy and dynamic range. The accuracy is much less audible on amplifiers, that are not seperated, electronicaly and physically.All receivers fall into this catagory.
So those who are not using seperate component for amplification will only notice a neglible change in sonic quality.
But if seperate amplifiers are used-and the wire has enough time to break in(40-60 hours)-amazing differences in inner detail and tonal balance is evident.
I defy any person ,in comparion of properly broken-in cables, using the some system, to declare that normal 12 gauage wire is the same as, say Cardas or any other meticulously designed high-end cable.