Randy has/had and Ep600 with 2 Ep350s and he claims it works very well. Others have run different subs/makes with good results as well.

I tried my PB13 with my old low powered sub and it made no difference, the PB13 drowned it out and the old sub just couldn't add enough to the equation.

Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70