You want to do a basic setup with an SPL meter and receiver tones and/or the built in Audyssey or other setup routines. It is important to have distances, crossovers, etc. setup correctly. Also, you can experiment with sub location, often the famous Alan sub crawl is what most of us use to find a good sub location.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85