The issues you could run in to would be similar to if you moved them closer or further away from a side wall, closer to or further from a back wall, more toe in, less toe in, or even if you put them into a different room... Room acoustics may pose a problem. Then again, it may make them sound better. It isn't an issue with the speaker, but how the sound coming from the speaker is reflected and absorbed in the room, how corners "boost" or "cancel" sound waves, etc.
Experimentation with placement is something that we all (should) do to some degree anyway. Starting off the ground a bit just means that you have a different starting point.
Good luck!
