Rust, small and large doesn't really have to do with the physical size of the speaker. It is more about setting the proper crossover to blend with your sub. If you have a sub in the mix, you normally want to set all speakers to small, and adjust the crossover for each speaker accordingly.

M80s VP180 4xM22ow 4xM3ic EP600 2xEP350
AnthemAVM60 Outlaw7700 EmoA500 Epson5040UB FluanceRT85