It also depends on the splice. I mean there are differences between twisting the wires and using electrical tape and soldering the connection and covering with shrink wrap. Of course there are options inbetween as well like using crimp connectors, etc...
But yes, you should be OK. Look at it like this. I have 12 gauge wire running in my walls of my theater. At the speaker end, it terminates at a wall jack, same with by my A/V gear. Then I have smaller (2-5 foot depending on the location) "patch" cables with banana plugs on each end. There are essentially 8 more "splice" or "connection" points than if the wire was connected directly to my speakers and my A/V stuff. The key is that everything is connected super tight.
Good luck.
