Thanks Mojo! I have a Yamaha AVR RX-A3070 which uses YPAO. I will use that first and tweak as required as you suggested. I do have an old sub that I just couldn't afford to replace yet. Maybe next year.

I have also read that many of the auto set-up capabilities tend to set the front speakers to "large" and many people change that to "small". Is this something I should also keep an eye on during setup?
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M5HPv4 In-wall LCRs
M2v4 In-Wall Rears
M3v4 In-Ceiling Atmos
Yamaha RX-A3070