In reply to:
Since you're going to be sitting maybe 7-8' away in the room size that you mentioned, you can definitely save money over what you've proposed. Use three M2s across the front and the QS4 surrounds.
I second this. I really don't think the M2s should be dismissed. The only advantage I can see of the M22s is extra volume. For sound quality and a typical listening level in that size of room, the M2s will be fine. I am considering M2s (or W2s) for my room of 12'x22.5' and I am sure they will be fine. Just make sure you have a decent subwoofer and crossover no lower than 80Hz (even 100Hz may work for that size of room).