Helping inlaws w/ a whole house audio system. I'm going to start w/ a single source/multi zone solution first.

My problem is trying to understand how to run multiple pairs of speakers in one room. Any suggestions on amps w/ diagrams that can get me started on how to understand this?

Oldskool Elan Home Systems carries most any product you'll need for whole house audio/video including 12 and 16 channel amps along with in wall speakers.

They also have a tutorial regarding what type of wire/cable to run for the various home systems. I have used some of their equipment and am pleased with it thus far ... Building A Home