I've got an 16x13 two story great room. The square footage isn't all that much (about 222) but the ceilings are very high. Any thoughts on a 5.1 system? I'll be purchasing an Outlaw 1050 rec.

Whether or not you will be using your system for stereo as well, I would get the following speakers:

M22ti
VP150 (or 100 if your budget does not allow)
QS8's
EP350(or 175 if your budget does not allow).

You will need the bigger speakers to fill the room. Plus, they are not only louder, they are also better. They project a better soundstage, have more accuracy, etc...

Some people would say you can put an M2i or an M22 as a center. I've tried my M22 as a center and I must it is good, but not as good at my VP150. It doesn't concentrate the sound to the center too much. I also like the way the VP150 plays human voices better. It sounds just slightly more natural and it can differentiate between voices a bit better.