As in does the cone/driver wear or degrade slightly to produce any audibly different tone. I'm just curious, my M60Ti's and company are now 8 years old and used almost daily, but I can't say I notice any difference at all since the day I unpacked them. Just curious.
This falls into my line of thinking with the speaker break-in myth, if breaking-in a speaker makes an audible difference after only a relatively few hours of use, how bad or how much more wear will the speakers sound/incur after 10 times that much use. I would think they would be useless as a speaker. Those rubber surrounds have a very long life.
I doubt you would be able to tell much of a difference without A/B testing.