Im a little confused about hooking up an 8 and 4 ohm speaker to my Anthem MCA 50 power amp. I Will be getting 4 ohm speakers for my fronts and center but the rears are 8 ohm. Do i need to do anything to the amp or my pre-amp to get this to work?

Thanks in advance.

no need to do anything this will work no problem...

So just plug and play? meaning I don't have to change and setting on my pre amp or amp?

yeup just plug and play..

... and play, and play, and play, and play ...

Seriously, you'll have a hard time walking away from the theater when you first get these set up.