My luck with the Harmony 1100 has put the failure rate at once a year. I'm currently on my third one. I plan on purchasing an IR extender so I can use both the original remotes and a Harmony One, if it has the ability to program activities.
I find the touch screen is only useable for so many touches, then fails. It also depends on how much you use it.
I felt I needed the Harmony 1100 because my equipment is in the room behind the TV. But an IR extender will accomplish the same thing and cost 1/3 as much.