You might have to move the left M80 to the other side of the opening (ie close to the sub). Other than that, it should work OK. It looks like your setup has a very slight angle between the couch and the TV (ie the couch is a couple of feet to the right of the TV) so this could work out really well.

The only problem with having the right hand M80 so close to the wall is that you will get lots of bass reinforcement, but you have enough depth in the room that you can probably keep them away from the back walls.

Anyways, I think it would work. Biggest concern is visually overpowering the room, although they will still be a bit smaller than the SVS (deeper but not as tall). It could work visually... what colour are you thinking about for the speakers ?

M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8