I guess I'm stating the obvious here; but "If" I were starting from scratch and didn't already have a system and was going with a flat panel TV display, then I suspect I would go with on, in-wall, speakers for the mains and center to complement the flat panel attributes.

I don't, at this point anyway, see how I would incorporate them for surrounds or rears, although if I had a set, they would in fact work beautifully in my dining room system!(which is currently utilizing Brand "X" speakers)