Randy,
Tile close to the flange. Do not need to touch it. Just make sure you have enough room to get that bolt in or out if needed. The height of the flange will depend on how the put it in and how thick your tiles are and how much thinset your using. This is not a concern. From my experiemce after putting in tile you should get the thickest wax ring or even double it up.
Good luck

M60's VP150 QS8's EP500 Denon3805