I have the 2805 Denon and started with the Auto Setup and then verified everything with a Radio Shack analog SPL meter. The settings were pretty good, I did tweek them somewhat.
In regards to the Room EQ stuff, I currently leave this feature off. In the beginning I had it on, and thought everything sounded pretty good. I'm guessing it was because Axiom speakers are so great. However, I know leave it off, andhave found I like the sound better this way. With it on, it emphasized the midrange frequencies to much. I don't think Axiom speakers need any help, the are simply wonderful.