Welcome Shawn,
I think you'd be thrilled with the sound of a pair of M60s over the Nuance, though to be fair, Nuance is a decent Canadian designed speaker in the tradition of neutral tonal quality, so I suspect you could use the Nuances with the VP100 and QS4s and get a reasonably seamless soundstage with a good tonal blend.
In your modest-sized room, the M22s would be excellent but you'd really need a sub for added bass extension. A sub with a 10-inch driver, like the EP175, would provide deep low bass with lots of power.
