Hi Jared, I am in a similar room setup as you. I am in the process of setting up and tweaking, but right now I can say I am glad I went with the M22/EP500 combo. When properly setup, the soundstage is seamless - I am noticing a solid bottom end and clear mids and highs for music, but I fiddled with the "Front-Large" option to get a fuller mid range guitar sound. For movies the bass just fills the room without feeling "boomy" (speakers set to "Small").
If you are purchasing for only movies -go with the M22/500, for a combo of music movies - m22/500. I cannot comment on music with the M60's but I would guess that M60's with 350 would do very well for music only.
