Well the EP500 sub from the Factory Outlet is $1,080 which is half your budget, so it might be hard to stay around 2K total when you throw in surrounds, center, and mains. Even if you purchased the m22 bookshelfs for your left/right, which are great combined with a sub, you would be over with the other speakers added. The EP350 is a good sub, and I owned one prior to the EP500, but my room is 8,000 cu ft.
What is your % of music versus movie watching? This may help decide. You could get the VP100 center versus the VP150 to save a little. Whatever you do, I highly recommend you get qs8's for your surrounds, they are unbelievable.
