Well, M80s vs. M22s plus a nice sub is a very close call I would assume. Aren't they both from Axiom? I own M60s and never heard either one, but I have read a lot in this forum, and specifically comparing M22s plus a sub VS. M80s for a 2 channel system. I'd also agree that I'd purchase M80s if I had to do it all over again. Also, there is price difference isn't it?

Axiom M60s, QS4s, VP100 Onkyo TX-SR804 Oppo 970HD Rotel RB-1080/RCD-1072 REL Q150E sub, PS 3