Scott, how will you be primarily using this room? If you prefer 2 channel stereo music (no sub), go for the M-60 floorstanders. However if you plan on mostly watching 5.1 movies and music with sub, 5.1 channel SACD and DVD-A, I think the m22 would be a better fit for you.
I have a 15x25x7 room with M22, sit about 10 feet away and the music is more than loud enough, especially with the EP500, which is a beast. And I do listen to music and movies LOUD
I usually do not listen to music in 2 channel mode, I have tweaked the sub to blend seamlessly with the mains.
