I home auditioned the M22s vs the M50s a couple years ago. I ordered the M50s because I felt that I wanted a speaker with more on the bottom end and I didn't think there would be much difference in the midrange between the two. Initially, I didn't hear that much of a difference. But, after a couple of weeks the differences became very clear and I just couldn't justify replacing the bookshelves with the more pleasing sounding M50s. Having said this, I will say that if I had never heard the M22s and had originally ordered the M50s, I would probably be in that club right now. If I would upgrade to a tower now, I would have to leap past the M50s and would probably go with the M80s. The M22s have spoiled me, and left me with an appetite for more, although I know the room doesn't need more. One of these days, I won't be able to resist and will order something I don't need.