The M80's are the best bet for a fair size room when you like to listen to music a lot.. They just have a lot going on with all those drivers.. Very full sound, etc.. But, I feel I still need a sub for Home Theater work..
I dont own 22's, but the same drivers are found in the VP150 and QS8's I own..
For music, they would be best in a small room..
My guess is, a pair of 22's AND a sub, would be fine in a small to medium size room for Home Theater..
It's all a game of pressure.. More speakers and tweeters, more presence.. Good sound pressure levels, without having to run the amp and the speakers at red line..



LFE ! The rest is just details..