M22s and a sub will fill that size nicely, my area is 16x12 and open to another 16x12 in an 'L' configuration. My M22s, VP100, and QS8s did the job extremely well. I just recently decided I wanted a little more fuller sound, so went to the M60s but they were not quite what I was looking for coming from the M22s. The M80s, after a quick listen at Mojo's, was closer to what I was accustomed to.
I think the M60s combined with your smaller area will be amazing. They were very impressive in my area. Had I not heard the M22s I know I would have been amazed at the sound from the M60s.
Let's make it easy, if the extra money for the M80s isn't a problem, nor the extra height and depth then get them. If any of these are a problem get the M60s. You will not be disappointed by either.
