Just to add to Randy's response, as it really does depend on all those variables, I did notice the difference in both instances I A/B'd the M80 and M60, and it was in 2 decidedly different rooms. I also felt the differences became minimal the louder you played the M60s, they sounded more like the M80s. At lower volume levels, say about 60-65db the M80s, IMO, reveal better detail and still have a better lower end.
Here is a
link to a comparison I did with another forum member.
If you go to the water cooler forum stickied to the top is an excellent search engine for Axiom's forums.