I upgraded from M22's to M80s and I love the better midrange/upper bass the M80s have over the M22s, it is more powerfull, prominent, IMO, particularly in 2 channel mode and for HT there is a more viseceral feel to explosions etc coming right at you from the lower XO the M80s offer. Having said all that, the M22/EP350 is a great combo(I ran my M22s with my PB13 Ultra) and you may not find as much difference as I did, as we all hear things a little differently.

Jason
M80 v2
VP160 v3
QS8 v2
PB13 Ultra
Denon 3808
Samsung 85" Q70