Justin, welcome. You haven't mentioned what receiver that you'll be using, but I'll suggest that using a surround mode such as DPLII gives a more realistic surround effect than just having all the speakers play the same sound("all channel stereo") if that's what you're talking about. The sound coming from the side speakers should be like the ambient sound that actually comes from the back and sides during the performance, rather than being identical to what comes from the front speakers.
A setup of two M22s plus two QS4 side surrounds should work very well. You don't mention a sub, but even for many types of music a small sub can add significantly to the effect.
