It will sound at least half-right though...

Should be no problem running with one of the woofers disconnected. Your receiver/amp will see a slightly higher impedence but that won't hurt anything.

M60ti, VP180, QS8, M2ti, EP500, PC-Plus 20-39
M5HP, M40ti, Sierra-1
LFR1100 active, ADA1500-4 and -8