I always have the crossover set to the maximum so it doesn't interfere with the setting.

having two speakers set at small and a sub sounds just fine in terms of getting the whole range of sound, but I much prefer the soundstage and imaging of just two speakers, so to get as much bass as possible, i set them to large. For just two channel listening, I likely would have been better off with M60's or M80's, but they are way over my budget. Perhaps next year I will buy a pair of towers, move the M22's to the back, and sell my M3's.