Hi tolson
I prefer the sound of the M3Tis to that of the M22s.
The M3s, in my opinion, are a better choice as a stand alone speaker, M3s go deeper, have a richer sounding midrange and lack very little up high. I've had both M3s and M22s, and again, I don't know if my M22s were a bit off or what, but to me the M3s sounded 'fuller,' sweeter, yet also accurate and detailed.
I also think the M3s are a superb speaker for use with tube amps - my 5 wpc tubie were perfectly adequate for the levels at which I listen to music - I could play these speakers to high volumes without things breaking up, but when I say "high" I'm not talking about window rattling levels, or playing head bashing rock at reference levels.