That depends on what you plan on using them for. Most people really like the sound of the M3ti when used in a 2 channel, no sub, small room setup.
The M22ti is most often used in a 2 channel plus sub setup or also they're very often used a main channels in a HT setup.
Once again it's not so much a matter of which is better. It's which is better suited for your needs. Axiom only has one line of speakers.
It seems that unlike many other companies which make a good, better, best line of speakers, Axiom makes one line of speakers, with each speaker designed for specific applications.
