Gary, if the same sub is used in both cases, obviously the bass handled by the sub will be the same in both.

As to the mid-range, keep in mind that the M22 uses two of the same 5 1/4" drivers, while the M60 uses one. Although this isn't a "huge" matter, the M22 does have the ability to play a bit louder in the all-important mid-range.

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Enjoy the music, not the equipment.