Athough the picture is not my room, it's almost identical. You can't put speakers to the sides of the wall because they will block the entries to the other room. The TV will take up most of the width of the upper wall and the fireplace will take up most of the bottom. I think a soundbar is my only option. However, Axiom's in-wall speakers may work on that wall too. I'd have to do some measurements.

M60s
VP150
QS8s
Marantz SR6003
Samsung LN52B550
Oppo DV-980H
Insignia NS-WBRDVD