I wouldn't think so. It's not a gyroscopic mouse; it's an optical. It's gotta have something to reflect off of.

I checked out mice today, and the Microsoft Intellimouse Explorer 4.0 is really comfortable. However, the reviews on Amazon were sort of negative on the gaming. I think I'm going to get the MX500, unless anyone has positive gaming experience with the new scroll/tilt wheels on the Intellimice. (feels really weird too, not having any clicks)

I am the Doctor, and THIS... is my SPOON!