Riley, welcome. 1)Yes, in my view, go with the M22s; 2)QS4s should be quite enough; 3)as surrounds they'll match the M22s as closely as they need to; 4) not sure what separation that you're referring to. The side surrounds should be opposite the sitting position and at least a few feet away. The back surrounds should be at least a few feet behind the sitting position and separated widely enough so that they're outside the edges of the couch or whatever.
Your suggested separation of 4.5' for the front speakers isn't enough. They should be separated about as much as your sitting distance, if possible, even if it means moving them out farther in front of the TV.
