The QS8's are the most adaptable speaker I have ever owned. I have positioned them in weird spots in 4 different apartments and they always sound fantastic and give an enveloping surround sound.

As for the VP100 and M50's, they will easily fill your space as long as the ceilings are not extremely high.

What kind of use is it for, mainly? Music or movies? What amp are you going to use with them?