Subwoofer long runs multiple connections.

Wife now wants sub EP 500 set up in back Left corner of room behind my King recliner char. I have a cable outlet there. Want to use that connection RG59 with multiple splices over the wall down the hall ending at the amp. Confirmed no short after connecting 3 runs of coax. Distance for total Coax is estimated at 100 ft.

Question? Will there be any sound quality issues with this long coax run.