Here goes from my desktop - beautiful home OSB! I have a friend with a similar room - a big A frame, pair of M60 like Michaura M665 towers and M22 like Michaura M55s in the back, a Merak Frankencenter we made together, and although I thought the room would be challenging acoustically, his system sounds beautiful.
I'm in Irvine. Maybe one day we can get together and do some listening to some Dahlquists, VS's, Michauras and Axioms! If we do it here, I'll throw on the steaks or veggie burgers depending on sensibilities.
Good luck in your new place.
Enjoy the Music. Trust your ears. Laugh at Folks Who Claim to Know it All.