As a recent proud owner of the M22's, I of course,
have to pimp those(surprise)! I think if you based your system around M22's as your mains, you cannot go wrong. They are fabulous speakers...
But from what I have gleaned from this forum and reviews found on the interweb, the M3's are a wonderful pair of speakers,
especially if you are not using a sub and are mainly into music listening. They would though, I'm sure, make an excellent front end for an HT set-up. And probably, like all Axioms, mate well with any of their other offerings.
Now, I do have a theory about using the M2's (not sure if anyone does this), which would be to set up a system with 5 M2's (or a VP100 for the center channel if you are more "movie-centric") for all the speakers, coupled with an Axiom (or other sub of equal or better quality) subwoofer.
I think an all M2's 5.1 system would create a seamless sound world for a smaller room or the budget minded audiophile.